The Keto HDAC Myth — How One Paper Misled Millions for a Decade

Jan 13th 2026 10:33pm EST

STORY AT-A-GLANCE A 2013 Science paper claimed beta-hydroxybutyrate (BHB), the primary ketone body produced during ketosis, was a potent histone deacetylase (HDAC) inhibitor with powerful epigenetic benefits — this claim became the foundation of the keto movement’s health narrative A devastating 2019 head-to-head comparison in Scientific Reports found that BHB shows no detectable HDAC inhibition […]

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