Mitochondrial Dysfunction Sparks Inflammation and Cancer Risk
STORY AT-A-GLANCE Suppression of mitochondrial ATP production prevents apoptosis and activates the NLRP3 inflammasome, a key player in inflammation and disease Inhibitors of oxidative phosphorylation (OXPHOS) lead to changes in mitochondrial cristae structure and retention of cytochrome c, which is necessary for NLRP3 activation but not sufficient on its own Activation of the NLRP3 inflammasome […]
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