Revisiting Depression — Dopamine-Serotonin Balance Gains Attention for Treatment-Resistant Depression

Nov 9th 2025 10:33pm EST

STORY AT-A-GLANCE A major clinical trial in The Lancet Psychiatry found that boosting dopamine with pramipexole improved symptoms in treatment-resistant depression. This challenges the long-dominant serotonin deficiency theory Supporting those findings, another study showed that agomelatine, a serotonin-blocking drug, consistently reduced anxiety and depression in multiple placebo-controlled trials Research shows polyunsaturated and monounsaturated fats (PUFs […]

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