New Research Undermines ‘Burn Fat to Lose Fat’ Claim in Obesity Treatment

Jan 28th 2026 10:33pm EST

STORY AT-A-GLANCE New research shows that restoring glucose oxidation through the PDH enzyme — not burning more fat — is the key driver of meaningful and sustainable fat loss Obese animals lost fat while preserving muscle once PDH activity was restored, revealing a metabolic repair pathway that supports long-term weight control and higher energy Human […]

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